Kyle MacLachlan is FBI Special Agent Dale Cooper
Michael Ontkean is Sheriff Harry S. Truman
Mädchen Amick is Shelly Johnson
Dana Ashbrook is Bobby Briggs
Richard Beymer is Benjamin Horne
Lara Flynn Boyle is Donna Marie Hayward
Sherilyn Fenn is Audrey Horne
Warren Frost is Dr. William Hayward
Peggy Lipton is Norma Jennings
James Marshall is James Hurley
Everett McGill is Big Ed Hurley
Jack Nance is Pete Martell
Kimmy Robertson is Lucy Moran
Ray Wise is Leland Palmer
Joan Chen is Josie Packard
Piper Laurie is Catherine Packard Martell
Eric DaRe is Leo Johnson
Harry Goaz is Deputy Andy Brennan
Michael Horse is Deputy Tommy 'Hawk' Hill
Sheryl Lee is Laura Palmer/Madeleine Ferguson
Russ Tamblyn is Dr. Lawrence Jacoby
Gary Hershberger is Mike 'Snake' Nelson
Don S. Davis is Major Garland Briggs
Mary Jo Deschanel is Eileen Hayward
David Patrick Kelly is Jerry Horne
Wendy Robie is Nadine Hurley nee Butler
Grace Zabriskie is Sarah Palmer
Chris Mulkey is Hank Jennings
Frank Silva is Bob
Kenneth Welsh is Windom Earle
Ian Buchanan is Dick Tremayne
Catherine E. Coulson is Margaret Lanterman, the Log Lady
Miguel Ferrer is FBI Agent Albert Rosenfield
David Lynch is FBI Regional Bureau Chief Gordon Cole
Charlotte Stewart is Betty Briggs
Michael J. Anderson is Mike
Jill Rogosheske is Trudy Chelgren
Victoria Catlin is Blackie O'Reilly Heather Graham is Annie Blackburn
Al Strobel is Philip Mike Gerard, the One-Armed Man